Mekelle University conducted a one day workshop to establish the Student One Health Innovations Club at College of Health Sciences and College of Veterinary Medicine on December 10th 2017. During the workshop, presentations were made on the historical development of one health approach and One Health Central and Eastern Africa (OHCEA) network. The workshop objective was to establish strong and vibrant clubs that will be responsible in disseminating knowledge to wider communities through various community outreach programs and sensitization of the public about zoonotic diseases. One hundred (100) students from veterinary medicine, public health, environmental health, nursing and medicine participated in the workshop and committed themselves to work together to address the health challenges at the human-animal and environment interface. The workshop was facilitated by Dr. Berihun Afera One Health Focal Person and Knowledge and Technology Transfer Officer at the College of Veterinary Medicine and Dr. Gebrehiwot Tadesse, OHCEA Board Member who is also Research and Postgraduate Director at Mekelle University.